Consumers seek low-fat fried products with appealing color, texture, and taste to avoid health issues like obesity and cardiovascular disease associated with high-oil-content foods. Frying conditions, including time and temperature, greatly affect the moisture, texture, oil content, and color of fried foods. The objective of this study was to optimize frying time and temperature to obtain quality fried chips from three varieties of orange- fleshed sweet potato roots. The study examined how frying temperature (ranging from 140 to 180°C) and time (2 to 6 mins) affect the quality of fried chips, assessing attributes like moisture content, oil content, color, and texture. Significant impacts of frying time and temperature on chip quality were found across all varieties using central composite design tests and mathematical models . Optimal frying conditions were determined through response surface methodology analysis, which was 154.8°C for 3.82 mins, 160.1°C for 3.66 mins, and 162.65°C for 3.04 mins for Kabode, Dilla, and Kulfo varieties, respectively, guiding sweet potato fried chip producers to achieve satisfactory results economically and efficiently.